The increasing use of cluster randomised trials in low-resource settings raises unique ethical issues. The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomised Trials is the first international ethical guidance document specific to cluster trials, but it is unknown if it adequately addresses issues in low-resource settings. In this paper, we seek to identify any gaps in the Ottawa Statement relevant to cluster trials conducted in low-resource settings. Our method is to analyse a prototypical cluster trial conducted (...) in a low-resource setting with the Ottawa Statement; to identify ethical issues in the design or conduct of the trial not captured adequately and to make recommendations for issues needing attention in forthcoming revisions to the Ottawa Statement. Our analysis identified six ethical aspects of cluster randomised trials in low-resource settings that require further guidance. The forthcoming revision of the Ottawa Statement should provide additional guidance on these issues: streamlining research ethics committee review for collaborating investigators who are affiliated with other institutions; the classification of lay health workers who deliver study interventions as health providers or research participants; the dilemma experienced by investigators when national standards seem to prohibit waivers of consent; the timing of gatekeeper engagement, particularly when researchers face funding constraints; providing ancillary care in health services or implementation trials when a routine care control arm is known to fall below national standards and defining vulnerable participants needing protection in low-resource settings. (shrink)

Lists of species underpin many fields of human endeavour, but there are currently no universally accepted principles for deciding which biological species should be accepted when there are alternative taxonomic treatments (and, by extension, which scientific names should be applied to those species). As improvements in information technology make it easier to communicate, access, and aggregate biodiversity information, there is a need for a framework that helps taxonomists and the users of taxonomy decide which taxa and names should be used (...) by society whilst continuing to encourage taxonomic research that leads to new species discoveries, new knowledge of species relationships, and the refinement of existing species concepts. Here, we present 10 principles that can underpin such a governance framework, namely (i) the species list must be based on science and free from nontaxonomic considerations and interference, (ii) governance of the species list must aim for community support and use, (iii) all decisions about list composition must be transparent, (iv) the governance of validated lists of species is separate from the governance of the names of taxa, (v) governance of lists of accepted species must not constrain academic freedom, (vi) the set of criteria considered sufficient to recognise species boundaries may appropriately vary between different taxonomic groups but should be consistent when possible, (vii) a global list must balance conflicting needs for currency and stability by having archived versions, (viii) contributors need appropriate recognition, (ix) list content should be traceable, and (x) a global listing process needs both to encompass global diversity and to accommodate local knowledge of that diversity. We conclude by outlining issues that must be resolved if such a system of taxonomic list governance and a unified list of accepted scientific names generated are to be universally adopted. (shrink)

Randomized controlled trial trial designs exist on an explanatory-pragmatic spectrum, depending on the degree to which a study aims to address a question of efficacy or effectiveness. As conceptualized by Schwartz and Lellouch in 1967, an explanatory approach to trial design emphasizes hypothesis testing about the mechanisms of action of treatments under ideal conditions, whereas a pragmatic approach emphasizes testing effectiveness of two or more available treatments in real-world conditions. Interest in, and the number of, pragmatic trials has grown substantially (...) in recent years, with increased recognition by funders and stakeholders worldwide of the need for credible evidence to inform clinical decision-making. This increase has been accompanied by the onset of learning healthcare systems, as well as an increasing focus on patient-oriented research. However, pragmatic trials have ethical challenges that have not yet been identified or adequately characterized. The present study aims to explore the views of key stakeholders with respect to ethical issues raised by the design and conduct of pragmatic trials. It is embedded within a large, four-year project that seeks to develop guidance for the ethical design and conduct of pragmatic trials. As a first step, this study will address important gaps in the current empirical literature with respect to identifying a comprehensive range of ethical issues arising from the design and conduct of pragmatic trials. By opening up a broad range of topics for consideration within our parallel ethical analysis, we will extend the current debate, which has largely emphasized issues of consent, to the range of ethical considerations that may flow from specific design choices. Semi-structured interviews with key stakeholders, across multiple jurisdictions, identified based on their known experience and/or expertise with pragmatic trials. We expect that the study outputs will be of interest to a wide range of knowledge users including trialists, ethicists, research ethics committees, journal editors, regulators, healthcare policymakers, research funders and patient groups. All publications will adhere to the Tri-Agency Open Access Policy on Publications. (shrink)

Background This study assessed patient perceptions of the Physician Payments Sunshine Act and opinions toward physicians who receive gifts and/or payments from pharmaceutical or medical device companies. Methods During their office visit, patients attending different specialty clinics volunteered to complete our survey. The survey asks if the patient knows what the Sunshine Act is, then asks questions on 5-point response scales to assess the patient's opinions toward physicians who receive compensation from companies, their self-rated knowledge of physician compensation, and how (...) they believe this compensation affects the cost of care. Results Over 13 months, 523 responses were collected: 8.6% of patients reported having knowledge of the Sunshine Act, 56.8% rated their knowledge of physician compensations as “poor,” and 67.1% agreed with the statement that patients should be aware of the compensation physicians receive. When asked how their opinion toward their physician would change if they learned the physician received free meals or gifts from companies, 58.9% replied “not at all,” and 36.11% of patients did not believe their cost of care would increase if their physician received compensation from companies. Conclusions Most patients were unfamiliar with the Sunshine Act, and believe their knowledge of physician compensation is poor. Over half of the respondents would not change their opinion of their physician based on knowledge of their physician receiving payments/gifts from companies, and over one-third of respondents did not believe such compensation increased the cost of care. The majority of respondents agreed that patients should be aware of payments/gifts to physicians. (shrink)

According to the moral encroachment thesis, moral features of a situation can affect not just what we’re practically justified in doing but also what we’re epistemically justified in believing. This paper offers a new rationale for that thesis, drawing on observations about the role of reflection in agency.

In general, stimuli that are familiar and recognizable have an advantage of predominance during binocular rivalry. Recent research has demonstrated that familiar and recognizable stimuli such as upright faces and words in a native language could break interocular suppression faster than their matched controls. In this study, a visible word prime was presented binocularly then replaced by a high-contrast dynamic noise pattern presented to one eye and either a semantically related or unrelated word was introduced to the other eye. We (...) measured how long it took for target words to break from suppression. To investigate word-parts priming, a second experiment also included word pairs that had overlapping subword fragments. Results from both experiments consistently show that semantically related words and words that shared subword fragments were faster to gain dominance compared to unrelated words, suggesting that words, even when interocularly suppressed and invisible, can benefit from semantic and subword priming. (shrink)

This paper reports an experimental investigation of presuppositions and scalar implicatures in language acquisition. Recent proposals posit the same mechanisms for generating both types of inferences, in contrast to the traditional view. We used a Covered Box picture selection task to compare the interpretations assigned by two groups of children and by adults, in response to sentences with presuppositions and ones with either ‘direct’ or ‘indirect’ scalar implicatures. The main finding was that the behavior of children and adults differed across (...) inference types. This asymmetry is consistent with the traditional perspective, but poses a challenge for the more recent uniform accounts. We discuss how the latter could be amended to account for these findings, and also relate the findings to previous results on presupposition processing. Finally, we discuss an unexpected difference found between direct and indirect scalar implicatures. (shrink)

von Fintel and Gillies : 329–360, 2007) have proposed a dynamic strict conditional account of counterfactuals as an alternative to the standard variably strict account due to Stalnaker and Lewis. Von Fintel’s view is motivated largely by so-called reverse Sobel sequences, about which the standard view seems to make the wrong predictions. More recently Moss :561–586, 2012) has offered a pragmatic/epistemic explanation that purports to explain the data without requiring abandonment of the standard view. So far the small amount of (...) subsequent literature has focused primarily on the original class of cases motivating the strict conditional view. What is needed in the debate is an examination of the predictions of the dynamic strict conditional account for a broader range of data. I undertake this task here, presenting a slew of cases that are problematic for the strict conditional view but not for Moss’s view, and considering some possible responses. Ultimately I take my contribution to constitute a significant blow to the dynamic strict conditional view, though not a decisive verdict against it. (shrink)

Deeply moved by his experiences in the trenches of the First World War, the Scottish philospher John Macmurray came to challenge the conventions inherited from European traditions of thought and mounted an assault on impersonal philosophies that failed to address needs and emotional reality.

Logic forms the basis of mathematics and is a fundamental part of any mathematics course. This book provides students with a clear and accessible introduction to this important subject, using the concept of model as the main focus and covering a wide area of logic. The chapters of the book cover propositional calculus, boolean algebras, predicate calculus and completelness theorems with answeres to all of the excercises and the end of the volume. This is an ideal introduction to mathematics and (...) logic for the advanced undergraduate student. (shrink)

Deference to experts is normal in many areas of inquiry, but suspicious in morality. This is puzzling if one thinks that morality is relevantly like those other areas of inquiry. We argue that this suspiciousness can be explained in terms of the suspiciousness of deferring to an epistemic peer. We then argue that this explanation is preferable to others in the literature, and explore some metaethical implications of this result.

This is the first single volume to offer a comprehensive and systematic account of British and American aesthetics from the early eighteenth century to the late twentieth century.

This paper advances a continuing line of research investigating the potential of web-based educative curriculum materials (ECMs) to facilitate teachers’ development of professional teaching knowledge (PTK). Our ECMs consisted of online lesson plans scaffolded with embedded digital resources to promote teacher understanding of a particular wise-practice pedagogy: problem-based historical inquiry (PBHI). Our research question was: Can a 2nd generation of web-based ECMs encourage social studies teachers’ development of PTK for PBHI? Participants reacted positively to several educative scaffolds, especially videocases of (...) experts modeling historical thinking. Evidence suggested that multiple experiences with planning and implementing instruction with our ECMs helped teachers recognize value in some of the materials’ underpinning concepts (e.g., scaffolding and inquiry-based instruction). However, planning instruction individually, the novelty of planning resources enhanced with digital resources, and certain contextual features of schooling such as inadequate focused time for planning seemed to frustrate the ECMs potential to promote teacher-learning. Here we suggest that ECMs function less effectively as stand-alone supports; however, employed in more formal contexts that feature collaboration, they may be able to provide valuable support for teachers’ professional development. (shrink)

The last several decades of research on counterfactual conditionals in the fields of philosophy and linguistics have yielded a predominant paradigm according to which the notion of similarity plays the starring role. Roughly, a counterfactual of the form A > C is true iff the closest A-worlds are all C-worlds, where the closeness of a world is a function of its similarity, in a certain sense, to the actual world. I argue that this is deeply misguided. In some cases we (...) may only care about the closest A-worlds, but quite often we care about some broader variety of A-worlds varying in closeness. After presenting several problem cases for the similarity-based paradigm, some new and some known, I propose an alternative paradigm for the semantics of counterfactuals, which introduces the notion of A-scenarios, understood roughly as different ways of making A true. According to this view, A > C is true iff all the contextually relevant ways of making A true also make C true. I then more carefully spell out a working view that formalizes this idea with greater precision, and explore the consequences of that version of the view. (shrink)

Abstract:This essay excavates the “spherical” and “global” ontological optics that have emerged from Martin Heidegger's thought considered in the context of the whole earth image and global climate change, focusing on the work of Timothy Ingold and Timothy Morton. Probing the boundaries of Morton's perspective in particular, I show how his global vision of Being ultimately reinscribes a fundamentally anthropocentric position in which the human “interior” is privileged and universalized while the inhuman “exterior” is either violently incorporated or altogether rejected. (...) I then propose an alternative vision of Being, one which avows a planetary optics while simultaneously emphasizing the unseen and unknown roiling beyond the boundaries of both spherical and global perspectives. I conclude by suggesting that this alternative vision can begin to be cultivated through attending to the works of Georges Bataille, whom a growing host of contemporary theorists have begun to identify as a resource for an ecological perspective that negotiates both the articulation and the transgression of the ontological and perspectival limits that separate the anthropocentric interior and the inhuman exterior. Bataille's exorbitant vision of Being sublates the dialectic of spherical and global perspectives, joining a consciousness of the limits of earth-bound human seeing-being to the ecstatic experience of a dynamic planet in the midst of an unfathomable cosmos. (shrink)

Scientific models are often said to be more or less general depending on how many cases they cover. In this paper we argue that the cardinality of cases is insufficient as a metric of generality, and we present a novel account based on measure theory. This account overcomes several problems with the cardinality approach, and additionally provides some insight into the nature of assessments of generality. Specifically, measure theory affords a natural and quantitative way of describing local spaces of possibility. (...) The generality of models can be understood as the measure of possibilities to which the models apply. In order to illustrate our view, we consider the example of structural genomics, the ongoing project of building three-dimensional models of biological macromolecules like proteins. Using measure theory, we interpret the practice of homology modeling, where such models are understood to apply widely but imperfectly to the space of possible proteins. (shrink)

A key issue in the philosophy of biology is evolutionary contingency, the degree to which evolutionary outcomes could have been different. Contingency is typically contrasted with evolutionary convergence, where different evolutionary pathways result in the same or similar outcomes. Convergences are given as evidence against the hypothesis that evolutionary outcomes are highly contingent. But the best available treatments of contingency do not, when read closely, produce the desired contrast with convergence. Rather, they produce a picture in which any degree of (...) contingency is compatible with any degree of convergence. This is because convergence is the repeated production of a given outcome from different starting points, and contingency has been defined without reference to the size of the space of possible outcomes. In small spaces of possibilities, the production of repeated outcomes is almost assured. This paper presents a definition of contingency which includes this modal dimension in a way that does not reduce it to the binary notion of contingency found in standard modal logic. The result is a conception of contingency which properly contrasts with convergence, given some domain of possibilities and a measure defined over it. We should therefore not ask whether evolution is contingent or convergent simpliciter, but rather about the degree to which it is contingent or convergent in various domains, as measured in various ways. (shrink)

Research has examined various cognitive processes underlying ethical decision-making, and has recently begun to focus on the differential effects of specific emotions. The present study examines three self-focused moral emotions and their influence on ethical decision-making: guilt, shame, and embarrassment. Given the potential of these discrete emotions to exert positive or negative effects in decision-making contexts, we also examined their effects on ethical decisions after a cognitive reappraisal emotion regulation intervention. Participants in the study were presented with an ethical scenario (...) and were induced, or not induced, to feel guilt, shame, or embarrassment, and were asked to reappraise, or not reappraise, the situation giving rise to those emotions. Responses to questions about the ethical case were evaluated for the quality of ethical sensemaking, perceptions of moral intensity, and decision ethicality. Findings indicate that guilt, shame, and embarrassment are associated with different sensemaking processes and metacognitive reasoning strategies, and resulted in different perceptions of moral intensity. Additionally, cognitive reappraisal had a negative impact on each of these factors. Implications of these findings for ethical decision-making research are discussed. (shrink)

Non-consensual organ procurement from prisoners in China raises serious questions regarding the ethics of Chinese transplant research. In their article, published in this issue of JME, Higgins and colleagues address these questions through the lens of publication ethics. They argue that, ‘while there are potentially compelling justifications for use [of unethical research] under some circumstances, these justifications fail when unethical practices are ongoing’.1 Consequently, they recommend non-publication of Chinese transplant research and call for a mass retraction of the articles identified (...) in their review.2 To support their argument, Higgins and colleagues appeal to internationally recognised guidelines from the WHO3 and the World Medical Association, which assert that ‘executed prisoners must not be considered as organ and/or tissue donors’ due to the inability to acquire valid consent.4 Failing to declare an immediate publishing moratorium for transplant research involving prisoners in China, they argue, ‘undermines efforts to stop transplant-related human rights abuses, taints the evidence base, and renders those who publish and use the research complicit in the continuing harm’.5 We agree with Higgins and colleagues that non-consensual organ procurement from prisoners in China is a crime against humanity. Ongoing human rights violations in Chinese prisons are well documented and universally condemned. We also agree that the subsequent use of data acquired from unethical research is morally complex. Nonetheless, Higgins and colleagues’ arguments leave us with three …. (shrink)

Group musical performance, especially large instrumental ensembles, present the outward appearance of an asymmetric, temporally immediate stimulus-response relationship between conductor and ensemble. Interestingly, anecdotal reports from both conductors and performers indicate a degree of variability in the timing of orchestral response to the conductor’s gestures. This observation is not present in anecdotal accounts of other instrumental ensemble settings, like wind bands, but commonplace occurrence among orchestral musicians indicates the potential presence of greater complexity in the observed relationship. This study investigates (...) both the quality and quantity of temporal lag between conductor and ensemble in two common instrumental ensemble configurations – wind bands and orchestras – in an effort to describe the interplay present within conducted group performance. The findings indicate that the anecdotally identified lag is present within all ensemble types, and that it presents a flexible, dynamic temporal relationship between conductor and ensemble. Additionally, both the quantity and quality of lag values are significantly different between ensemble types, experience levels, and musical content. Several avenues for future research are identified, and confounds within the sampled ensembles are examined for their potential roles in the observed relationships. (shrink)

In 2018 the Congregation for the Doctrine of the Faith issued a responsum ad dubium, addressing the question of whether a hysterectomy is morally licit in cases wherein miscarriage is foreseen with medical certainty if the woman were to conceive. The CDF responded in the positive, explaining that “it does not regard sterilization.” The responsum provoked great controversy, with some commentators wondering at the prudence of issuing the teaching, and others questioning whether it represented a departure from the Catholic moral (...) tradition. This paper looks at a further area of concern in the reasoning of the responsum, namely that it departs from an essentialist account of the human person and of the organs and systems within the human body, and it moves toward a functionalist account of the meaning of the body and bodily systems as arising from whether they are functional. This represents a distressing shift in language from the previous hermeneutic employed by the magisterium, which could open the door to further controversy. (shrink)

The last few decades have witnessed an explosion in ideas and theories on art. Art itself has never been more popular, but much recent thinking remains inaccessible and difficult to use. This book assesses the work of leading thinkers (including artists) who are having a major impact on making, criticizing and interpreting art. Each entry, written by a leading international expert, presents a concise, critical appraisal of a thinker and their contribution to thought about art and its place in the (...) wider cultural context. A guide to the key thinkers who shape today's world of art, this book is a vital reference for anyone interested in modern and contemporary art, its history, theory, philosophy and practice. (shrink)

This article discusses Richard Kearney’s multidisciplinary trilogy on the role of ‘Philosophy at the Limits’: On Stories (2002), Strangers, Gods and Monsters (2002) and The God Who May Be (2001). The three books take a cross-cultural approach on the margins of philosophy, the first issuing an ethics of narrative, the second welcoming the figures of Otherness, and the third affirming that God neither is nor is not but may be. Promoting a middle way between subordinating the Same to the Other (...) and subordinating the Other to the Same, Kearney adopts the hermeneutic method to argue for the importance of faith as well as reason. (shrink)

Due to the wide array of phenomena that are of interest to them, psychologists offer highly diverse and heterogeneous types of explanations. Initially, this suggests that the question "What is psychological explanation?" has no single answer. To provide appreciation of this diversity, we begin by noting some of the more common types of explanations that psychologists provide, with particular focus on classical examples of explanations advanced in three different areas of psychology: psychophysics, physiological psychology, and information-processing psychology. To analyze what (...) is involved in these types of explanations, we consider the ways in which law-like representations of regularities and representations of mechanisms factor in psychological explanations. This consideration directs us to certain fundamental questions, e.g., "To what extent are laws necessary for psychological explanations?" and "What do psychologists have in mind when they appeal to mechanisms in explanation?" In answering such questions, it appears that laws do play important roles in psychological explanations, although most explanations in psychology appeal to accounts of mechanisms. Consequently, we provide a unifying account of what psychological explanation is. (shrink)

The purpose of this paper is to explore corporate perspectives on the development and use of sustainability reports. Interviews with experts from 35 Canadian corporations were conducted. The research showed that the content of the reports was determined by following standards, conducting an internal evaluation, and other methods. Five corporations were found to develop fully integrated reports, while another 15 included some sustainability aspects in their annual reports. The extent of external stakeholder involvement in the development of the report varied (...) widely, but the majority of the corporations considered stakeholder input. Data collection was handled by a number of different individuals and groups, with sustainability departments often taking a lead role. Twenty-five corporations relied exclusively on internal personnel to write the report, with the remaining corporations using a combination of internal and external writers. A number of key challenges in developing sustainability reports were identified, including timelines, data collection, selecting content, and striking an appropriate balance in reporting. The reports were used internally in a number of different ways, including enhancing employee awareness and engagement and as an internal reference tool. A number of potential future uses of sustainability reports were also mentioned, such as improving the ability to track real-time performance. (shrink)

Regress arguments show that to do something for a reason, one does not have to have reflectively endorsed that reason. This might seem to establish that reflection does not play a fundamental role in agency. This paper argues that this conclusion rests on too narrow a conception of agency. If agents are not just creatures who act for reasons but also creatures who can take ownership of the reasons for which they act, then there is a central role for reflection (...) to play in agency even if it's not the role that philosophers of action have typically envisioned for it. (shrink)

Pope Francis’s encyclical on ecology addresses the deep and abiding problems of atomism, exploitation, and prodigality that distort the God–human-nature relationship. The invitation to think and act in more integrated and integrating ways—already put forward in Evangelii gaudium—thwarts our becoming “nomads without roots” and binds ostensibly disparate voices in a solidarity that is truly global in its reach. The resolve for such a change in worldview and agency is reminiscent of Van Rensselaer Potter’s original conceptualization of bioethics as a field (...) of study and application that would bridge the disciplines. (shrink)

The Resurrection, like many other fundamental elements of the Christian Creed, stands outside the province of empirical science. If something that constitutes a mainstay feature of a person’s belief system cannot be measured by the standard tools and methods of the day, does this make it any less credible? Does immeasurability require a radical reformation of our understanding of the objects and principles of faith in order that they become more accessible to the reach of contemporary science, or does their (...) immeasurability discount them altogether? This essay reflects on James Carroll’s rejection of the bodily resurrection of Jesus and its implications for Roman Catholic bioethics. National Catholic Bioethics Quarterly 12.2 (Summer 2012): 227–234. (shrink)

For years, experimental philosophers have attempted to discern whether laypeople find free will compatible with a scientifically deterministic understanding of the universe, yet no consensus has emerged. The present work provides one potential explanation for these discrepant findings: People are strongly motivated to preserve free will and moral responsibility, and thus do not have stable, logically rigorous notions of free will. Seven studies support this hypothesis by demonstrating that a variety of logically irrelevant (but motivationally relevant) features influence compatibilist judgments. (...) In Study 1, participants who were asked to consider the possibility that our universe is deterministic were more compatibilist than those not asked to consider this possibility, suggesting that determinism poses a threat to moral responsibility, which increases compatibilist responding (thus reducing the threat). In Study 2, participants who considered concrete instances of moral behavior found compatibilist free will more sufficient for moral responsibility than participants who were asked about moral responsibility more generally. In Study 3a, the order in which participants read free will and determinism descriptions influenced their compatibilist judgments—and only when the descriptions had moral significance: Participants were more likely to report that determinism was compatible with free will than that free will was compatible with determinism. In Study 3b, participants who read the free will description first (the more compatibilist group) were particularly likely to confess that their beliefs in free will and moral responsibility and their disbelief in determinism influenced their conclusion. In Study 4, participants reduced their compatibilist beliefs after reading a passage that argued that moral responsibility could be preserved even in the absence of free will. Participants also reported that immaterial souls were compatible with scientific determinism, most strongly among immaterial soul believers (Study 5), and evaluated information about the capacities of primates in a biased manner favoring the existence of human free will (Study 6). These results suggest that people do not have one intuition about whether free will is compatible with determinism. Instead, people report that free will is compatible with determinism when desiring to uphold moral responsibility. Recommendations for future work are discussed. (shrink)